Goals from Xavi, Pedro, a double from David Villa and a last-gasp effort from Jeffren saw Barcelona secure a victory that sends them top of the Primera Liga and inflicted the worst defeat of Mourinho's career.
Real also saw Sergio Ramos dismissed late on at Camp Nou but although he admitted his team played poorly, Mourinho denied the result represented a full-scale embarrassment for his side.
"One team played very good, one team very bad," Mourinho said. "One deserved to win and deserved to lose. Humiliated? No. It's easy to deal with this loss, we just weren't good enough.
"We gifted them two goals that were almost ridiculous. I was watching the game. I tried to change things at the interval and we came out quite well, but then they scored again and there was nothing I could do - the game was lost.
"Last week we had a point more than Barcelona and today we have a point less. And as I have always said, Barca is the finished article while Madrid is still a long way off that."
Guardiola - who when asked if this result could result in Mourinho's departure, as an 8-0 win over Almeria saw Juanma Lillo lose his job, replied: "I don't think so" - said of the result: "'This match isn't representative of the difference between the two teams. They are a very good team, they came here unbeaten and as league leaders. Today all of our players played well and that was the difference.
"Now it's very easy to we are better than them, but only time will tell. In a few years time, we will see. They are on a spectacular level, but we were better today.
"In these two years we have been superior to Madrid - that's true. With time, we can enjoy these things more,'' he said. And we will enjoy this for a few days now as well."
Villa, who converted following two superb passes from Lionel Messi, said: "It's been a very important win. We looked for the victory and we got it. And the result and the manner in which we achieved it, you cannot ask for more.
"We are two points clear. We need to continue working hard. We are in November. Just as before the game nothing was lost, now neither have we won anything. We have an advantage but we need to continue working."
Real midfielder Xabi Alonso insisted that all is not yet lost in La Liga after Real suffered their first defeat of the season.
"We didn`t expect a game like this but there's a lot of the season left and this isn't over," Alonso told AS. "They have made things a lot easier for themselves by scoring the first so early and then getting the second quickly. It's been very difficult. We have to learn from the mistakes we've made."
15] Sesiapa yang keadaan usahanya semata-mata berkehendakkan kehidupan dunia dan perhiasannya (dengan tidak disaksikan sama oleh Al-Quran tentang sah batalnya), maka Kami akan sempurnakan hasil usaha mereka di dunia, dan mereka tidak dikurangkan sedikitpun padanya.  Merekalah orang-orang yang tidak ada baginya pada hari akhirat kelak selain daripada azab neraka, dan pada hari itu gugurlah apa yang mereka lakukan di dunia, dan batalah apa yang mereka telah kerjakan.
- Pemimpin Yang Menipu Rakyat
Ka’ab bin Ujrah r.a. berkata bahawa Rasulullah s.a.w bersabda: Akan datang di kemudian hari nanti, setelah aku tiada; beberapa pemimpin yang berdusta dan berbuat aniaya. Maka barang siapa yang membenarkan kedustaan mereka dan membantu (mendukung) tindakan mereka yang aniaya itu, maka ia bukan termasuk umatku, dan bukanlah aku daripadanya. Dan ia tidak akan dapat sampai datang ke telaga (yang ada di syurga);- (Riwayat Tirmidzi, Nasae’i dan Hakim).